Cancer Research-R03 Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain
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چکیده
Jinyu Chen, Ho-Jeong Lee*, Xuefeng Wu*, Lei Huo*, Sun-Jin Kim*, Lei Xu, Yan Wang , Junqing He, Lakshmi Reddy Bollu, Guang Gao, Fei Su, James Briggs, Xiaojing Liu, Tamar Melman, John M. Asara, Isaiah J. Fidler, Lewis C. Cantley, Jason W. Locasale and Zhang Weihua , Department of Biochemistry and Biology, College of Natural Science and Mathematics, University of Houston, Houston, TX , Department of Cancer Biology, MD Anderson Cancer Center, The University of Texas, Houston, TX , Department of Pathology, MD Anderson Cancer Center, The University of Texas, Houston, TX , Division of Nutritional Sciences, Cornell University, Ithaca, NY , Division of Signal Transduction, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School Boston, MA , Department of Medicine, Harvard Medical School, Boston, MA , Department of Medicine, Weill Cornell Medical College, New York, NY
منابع مشابه
Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain.
Breast cancer brain metastasis is resistant to therapy and a particularly poor prognostic feature in patient survival. Altered metabolism is a common feature of cancer cells, but little is known as to what metabolic changes benefit breast cancer brain metastases. We found that brain metastatic breast cancer cells evolved the ability to survive and proliferate independent of glucose due to enhan...
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تاریخ انتشار 2014